Are you in the process of getting fit and obtaining the body you always wanted? But endless hours in the gym do not give the results you were hoping for? Perhaps it’s time to give supplements a try? And we wish to help you reach your goal. Of course, you should never try random supplements. Before taking anything you must do research and even ask a nutrition specialist before trying any supplement. That’s the case for Cardarine as well.
Also known as GW501516 (and GSK-516, GW1516, Peroximod, Hennos), Cardarine having a chemical formula C21H18F3NO3S2 that caught the attention of many fitness enthusiasts and athletes around the globe. It has proven to be very efficient for shredding fat, increasing endurance, and so forth. However, we don’t aim to just list a series of benefits you get from using Cardarine. We’ve been through the best cardarine research material available right now and hundreds of Cardarine reviews to deliver a complete article on this supplement.
So, no matter if it’s the first time you hear about this chemical or thought about giving it a try – this article is for you. You’ll get valuable information on what GW 50156 is, how it works, effects, dosage, side effects, and everything you need to know before trying it.
What is Cardarine (GW501516)?
Cardarine is a supplement that is often referred to as a SARM. However, a more accurate description would be that it is a PPARδ receptor agonist. In other words, it can accelerate fat loss and increase body endurance. It was developed for the benefits it has shown on blood vessels, heart, and diabetes. In the research for substances that could help with fat burning in sedentary adults, scientists explored the PPAR-delta option. It was known that activation of PPAR-delta results in an energy boost, muscle building, fat burning, and decreased lipids. However, during the development, when the supplement reached Phase II of testing on animals, there were some concerns that Cardarine can cause cancers.
Some of the scientists who first discovered the chemical and proposed detailed studies argue that the risk of cancer has not been entirely proven. Furthermore, they sustain that the lack of long-time testing on humans makes the results gotten in Phase II on animals incomplete. Even with this dispute, it is safe to conclude that the Cardarine supplement is controversial, to say the least. It should be used only after understanding the full effects on your body. That’s exactly what we’re going to do in this article, provide you with in-depth data and information about Cardarine pills to help you decide if it’s a good idea to try it.
A Brief History
We can’t provide the best Cardarine 2020 review without starting with a brief history of how the drug reached the level of popularity it has today. Everything began in 1992 when Ligand Pharmaceuticals and GSK started a research collaboration on various methods to boost fat burning and enhance endurance.
The first official document about the GW501516 results was published in 2001. In the Proceedings of the National Academy of Sciences of the United States of America, the scientists reported that through structure-based drug design and combinatorial chemistry, they found this new chemical that promotes the reverse of cholesterol transport.
The promising idea that the Cardarine cycle could be used to treat hyperlipidemia pushed the supplement into the phase I trials as early as 2000, as reported by the R&D Focus Drug News. Everything continued as planned, and by 2007 the supplement already successfully completed 2 of phase II clinical studies that included positive effects on diabetes, obesity, and cardiovascular disease. However, further research was dropped later in 2007 after animal testing showed cancers developing rapidly with dosages of 3 mg/kg/day in mice and rats.
Despite these results, the laboratory run by Ronald Evans bought a sample of Cardarine and administered a much higher dose than what GSK used in its experiments. The results about its effects on dramatically increasing physical performance in mice quickly circled the globe as they were reported in publications such as The Wall Street Journal and the New York Times.
The publicity it got as a performance enhancer made Cardarine GW 501516 extremely popular, and concerns were raised before the 2008 Olympics in Beijing that it could be used by athletes to gain an unfair advantage since it wasn’t regulated to be detected in tests. As early as 2011 the supplement was available on the black market and heavily promoted on bodybuilding sites. This led to the World Anti-Doping Agency (WADA) issuing a very rare warning to potential users that the supplement comes with health risks.
Is Cardarine a SARM?
No. Unlike SARMs that activate the androgen receptors in certain tissues to increase muscle mass and reduce fat tissue, Cardarine is a PPAR-delta activator. It does not have an effect on androgen receptors. Instead, it activates the PPAR-delta pathway, a different approach compared to what SARMs do.
How Does Cardarine Work?
Cardarine is designed to start working shortly after ingestion. It binds to the PPAR-delta receptor and tells the liver to start drawing energy from fatty acids. In other words, Cardarine convinces the body to stop using the glucose in your blood as an energy source and switch to fatty acids for energy. This leads to accelerated fat loss. Also, since the PPAR-delta agonist processes mainly target skeletal muscles, it will accelerate the production of type 1 muscle fibers. That’s why bodybuilders promote Cardarine results as similar to regular exercise since it leads to these types of fibers that are usually produced by rigorous workouts.
Laboratory Tests of Cardarine
Besides the GW-05156 tests conducted by GSK, a number of studies were conducted on both animal and human subjects. Here are the most important ones and their conclusions.
· By combining the PPAR-delta activation pathway generated by Cardarine and exercise training, scientists observed a boost in oxidative myofibers and endurance while running in mice. Even more than that, the endurance increase was also observed in mice that were sedentary.
· Cardarine plays an important role in improving stem cells functions. These cells are of extreme importance for the human body as they provide the source for all other cell types.
· GW1516 also helps regulate brain inflammation by decreasing the myelin loss in brain cells. In other words, the supplement is also an anti-inflammatory that helps reduce the demyelination of neurons.
· PPAR-delta agonists such as Cardarine play a crucial role in storing and breaking down dietary fats, thus helping fight obesity and other metabolism disorders. Also, the positive effects of fat reduction through Cardarine on reducing cancer risk are being studied.
· Using GW051516 has shown promising results towards improving available insulin resistance treatments.
· PPAR-delta agonists also show a promising effect on lowering triglycerides and lipoproteins in fatty liver disease patients. This improves liver function and insulin sensitivity.
Boosts Stamina and Endurance
As shown in the research of Ronald Evans, Cardarine dramatically improves physical endurance and stamina. This happens when the activation of PPAR-delta using Cardarine led to increased development of type 1 muscle fibers in mice. Since these fibers are associated with overall muscle growth and are normally produced during sustained training, Cardarine’s role in boosting stamina and endurance can’t be denied.
The production of type 1 muscle fibers without the need for physical exercise makes GW1516 a muscle growth and stamina booster.
Reduced Brain Inflammation
According to studies conducted on mice with brain inflammation, the administration of Cardarine improves blood circulation and reduces oxidative stress. This comes to back up the anti-inflammatory effects observed in previous studies that confirmed Cardarine’s role in decreasing myelin loss in brain cells. However, with certain inflammatory substances such as IL-6, Cardarine had an opposite effect leading to an increase in inflammation.
This doesn’t take away GW051516’s anti-inflammatory effects. However, further tests in this area are recommended.
One of the main benefits that Cardarine was studied for, to begin with, is its ability of fat burning. As previously explained, the PPAr-delta activates the genes involved in getting energy from fat tissue instead of glucose. More recent studies on humans indicated that administering a daily dose of 2.5 mg of cardarine over the course of six weeks led to a decrease in fatty acids, triglycerides, and VDLD proteins.
While we can’t deny that Endurobol, one of the many names attributed to GW50156, has positive effects on fat burning, the available studies don’t provide high-quality evidence.
Reducing the Risk of Obesity
A study on six overweight volunteers who were given Cardarine confirmed that the supplement is associated with reducing obesity. Liver fat was reduced by up to 20%, while insulin also dropped by 11%. Furthermore, blood fats dropped, on average, by 23%.
This study concludes that the administration of Cardarine has positive effects in avoiding obesity, even with existing metabolic disorders. These results also back-up the initial belief that Cardarine enhances insulin sensitivity and reduced blood lipids.
Increases Growth of Blood Vessels and Prevents Oxidative Damage
On top of its effects in lowering cholesterol levels, this supplement can produce a direct effect on blood vessels. A certain degree of protection against oxidative damage to blood vessels was observed in mice. This can lead to a lower risk of plaque building up in arteries. Also, the above-mentioned anti-inflammatory effects of Cardarine can help reduce heart disease risk by clearing up the blood vessels.
Even more than that, Cardarine may be responsible for increasing numbers of blood vessels in humans’ heart cells. Even though it needs further research, this could prove to be useful for patients with heart disease.
Prevents Liver Damage
By telling the liver to switch from glucose to fatty acids as an energy source, Cardarine also helps to prevent liver damage. This happens because administrating Cardarine produced less IL-6 inflammatory substance in mice. The lower values of IL-6 are linked with insulin resistance prevention. The study results showed that mice suffered lower liver damage when put on a high-fructose diet.
Cardarine Side Effects
Possible Liver Damage
Using Cardarine to prevent liver damage is a two-way street, though. As mice with existing liver disease developed fibrosis and an acceleration of the negative effects of liver disease. So, once more, you should consult with a doctor before taking Cardarine.
Even though the anti-inflammatory effects have been thoroughly documented, there were cases when Cardarine increased inflammation. Especially when interacting with IL-6, the supplement had an opposite effect leading to an increase of inflammation.
Does Cardarine Cause Cancer?
The initial GSK study on this substance was suddenly dropped in 2007 after very promising results. It was later discovered that serious concerns about the supplement causing cancers was the reason for stopping development. There was a strong debate among scientists about the potential of GW501516 to cause cancer in humans, an idea backed up by the performance-enhancing effects observed by Evans. However, the results from animal testing can’t be totally ignored. While it’s true that prolonged human tests would be required to settle this one once and forever, that’s not going to happen since it’s considered too risky. The bottom line is that it has the potential to cause cancer in mice and there’s a very low chance that it could do the same to humans.
Is Cardarine Legal?
No, Cradarine is not legal and it’s also not approved for use in humans. Thanks to heavy promotion in magazines like The New York Times, GW501516 enjoys a spike in popularity, however, it’s only available on the black market as a research chemical. Furthermore, the very rare warning issued by the WADA about Cardarine backs up the idea that the supplement is not legal.
Cardarine Dosage & Cycle
When talking about Cardarine dosage, you should know that it’s different depending on your experience and fitness level. For example, if it’s your first time trying a supplement like GW-501516, a 10 mg daily dose is more than enough. You should take the 5mg for two weeks for optimum effect and minimal negative effects.
If you’re an intermediate and you tried Cardarine or other supplements before, you can go up to 10mg per day. The cycle can also be increased to 4 weeks but you should immediately stop if you feel something’s wrong.
Advanced bodybuilders that have experience with such substances can go as high as 20 mg daily for up to 6 weeks. If you plan to cut a lot, the recommendation is to take 10 mg in the morning and the other 10mg before sleep.
· 5 mg per day for beginners
· 10 mg daily for intermediate
· 20 mg per day for experts
We, once more, want to highlight that Cardarine is a potentially dangerous drug. It was developed for its fat-burning and performance-enhancing potential, however, the research stopped when various cancers started developing in mice.
After being covered by magazines like The Wall Street Journal or New York Time, Cardarine gained huge popularity, despite its potential side effects. It was promoted as a muscle growth and fat-burning supplement but there’s some evidence pointing to potential liver damage, especially in individuals with pre-existing liver disease.
Various forums and retailers downplay the potentially harmful effects of GW501516, however, we want to underline that there are dangers associated with this chemical. Therefore, our recommendation is to refrain from taking this supplement.
Testimonials about results achieved using Cadarine include losing up to 10lbs in just 6 weeks using the supplement. While that’s an achievable weight cut, it can’t be done without a thoughtful caloric intake and proper exercise. If used for cutting, Cardarine can be combined with another supplement to assist with muscle mass preservation. Ostarine and Cardarine go hand in hand in this case.
Other users report a muscle gain of between 8 to 10 lbs and an up to 5% body fat reduction when using GW 50156. With a daily dose of 15 mg of Cardarine and 5 mg of Ligandrol for a cycle of 8 weeks. That’s a serious body transformation in just 8 weeks without having to worry about intaking the best peptides or anything like that!
As for its endurance enhancing properties, a runner reported getting a result of 4 minutes 55 seconds per mile within 7 weeks after starting a Cardarine cycle of 8 weeks. This happened after months of being stuck in the 7-minute area before trying the supplement. Furthermore, endurance was also enhanced with runners claiming they spent 1 hour on the treadmill at 7 speed without feeling assed.
Cardarine GW501516: User Reviews
We’ve found a very few reviews on Cardarine. For instance, we’ve checked Russian bodybuilding forum and found that this supplement was well-known at least since 2015 and there’s no any risks reported. For the current time, you can’t find other relevant information at the forums.
Looking at scientific research, saying that this supplement improves fat burning while also improving performance is accurate. There are various other benefits such as cleaner and healthier blood vessels or even obesity prevention. However, since animal tests also confirmed fast-developing cancer in animal trials, you should be very careful. Always consult a doctor before taking any supplement or drug, especially when talking about a chemical that is not approved for human consumption. Once again, our recommendation is not to take Cardarine under any circumstances. However, at the end of the day, it’s a personal decision to make. At least you have one of the best Cardarine 2020 reviews to consult over and over if you are still making up your mind.